BDBM23515 CHEMBL573::Niacin::Nicotinic Acid::[5, 6-3H]-niacin::pyridine-3-carboxylic acid::wampocap
SMILES OC(=O)c1cccnc1
InChI Key InChIKey=PVNIIMVLHYAWGP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 58 hits for monomerid = 23515
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataKi: 33nMAssay Description:Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 50nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 82nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 104nMAssay Description:Displacement of [3H]NA from cloned human GPR109A receptor expressed in CHO-K1 cells by spectrophotometry in presence of 4% human serum albuminMore data for this Ligand-Target Pair
Affinity DataIC50: 140nM EC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Membranes were incubated in binding buffer with [5, 6-3H]-niacin in the presence of test compound. After 4 hours at room temperature, reactions were ...More data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 7.59E+4nMAssay Description:Agonist activity at human GPR109b expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: 8.70nMAssay Description:Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Activity at GPR109a in CHO cells assessed as inhibition of forskolin-induced cAMP generationMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production testMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human GPR106A by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from human GPR109AMore data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+3nMAssay Description:Agonist activity at human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS guanine nucleotide exchange assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human GPR109A receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataEC50: 670nMAssay Description:Agonist activity at rat GPR109A expressed by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from human GPR109A expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human GPR109A expressed in CHOK1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 730nMAssay Description:Activation of GPR109A in human A431 cells assessed as suppression of forskolin-induced cAMP production after 30 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 527nMAssay Description:Agonist activity at cloned human GPR109A receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CHO-KI cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human niacin receptor expressed in CHO-KI cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR10a receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]nicotinic acid from human GPR10a receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Displacement of [3H]niacin from GRP109A receptor in presence of 4% human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from GRP109A receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Agonist activity at rat GPR109aMore data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:Agonist activity at mouse GPR109aMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Agonist activity at human HM74AMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in absence of 5% human serumMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]niacin from human niacin receptor expressed in CKO-K1 cells in presence of 5% human serumMore data for this Ligand-Target Pair
Affinity DataEC50: 1.00E+3nMAssay Description:Agonist activity at human niacin receptor expressed in CKO-K1 cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6.73E+4nMAssay Description:Agonist activity at GPR109A receptor expressed in CHOK1 cells assessed as inhibition of forskolin-induced intracellular cAMP production by Flashplate...More data for this Ligand-Target Pair
Affinity DataEC50: 580nMAssay Description:Activation of GPR109A receptor in CHOK1 cells assessed as ERK1/2 MAP kinase activation by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]nicotinic acid from mouse GPR109a receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 27nMAssay Description:Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 780nMAssay Description:Agonist activity at human recombinant GPR109a transfected in african green monkey COS-7 cells after 20 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataEC50: 99nMAssay Description:Agonist activity at human recombinant GPR109a expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GPR109bMore data for this Ligand-Target Pair
Affinity DataEC50: 29nMAssay Description:Agonist activity at mouse GPR109aMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Rattus norvegicus)
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Leiden/Amsterdam Center For Drug Research
Curated by ChEMBL
Affinity DataEC50: 39nMAssay Description:Agonist activity at rat GPR109aMore data for this Ligand-Target Pair
Affinity DataEC50: 51nMAssay Description:Agonist activity at human GPR109a expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP production by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.75E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
Affinity DataEC50: 2.73E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated c...More data for this Ligand-Target Pair